Nouns

(n)damage, harm, impairmentthe occurrence of a change for the worse
(n)deterioration, impairmenta symptom of reduced quality or strength
(n)disability, disablement, handicap, impairmentthe condition of being unable to perform as a consequence of physical or mental unfitness“reading disability”, “hearing impairment”
(n)impairmentdamage that results in a reduction of strength or quality
(n)stultification, constipation, impairment, deadeningthe act of making something futile and useless (as by routine)