Nouns

(n)kernel, substance, core, center, centre, essence, gist, heart, heart and soul, inwardness, marrow, meat, nub, pith, sum, nitty-grittythe choicest or most essential or most vital part of some idea or experience“the gist of the prosecutor's argument”, “the heart and soul of the Republican Party”, “the nub of the story”
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(n)essenceany substance possessing to a high degree the predominant properties of a plant or drug or other natural product from which it is extracted
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(n)effect, essence, burden, core, gistthe central meaning or theme of a speech or literary work
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(n)perfume, essencea toiletry that emits and diffuses a fragrant odor
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