Adjectives

(a)significant, importantimportant in effect or meaning“a significant change in tax laws”, “a significant change in the Constitution”, “a significant contribution”, “significant details”, “statistically significant”
(s)significant, substantialof considerable importance, size, or worth“won by a substantial margin”
(a)significanttoo closely correlated to be attributed to chance and therefore indicating a systematic relation“the interaction effect is significant at the .01 level”, “no significant difference was found”
(s)meaning, pregnant, significantrich in significance or implication“a meaning look”, “a significant silence”