Nouns

(n)pain, hurtinga symptom of some physical hurt or disorder“the patient developed severe pain and distension”
(n)pain, painfulnessemotional distress; a fundamental feeling that people try to avoid“the pain of loneliness”
(n)pain, pain sensation, painful sensationa somatic sensation of acute discomfort“as the intensity increased, the sensation changed from tickle to pain”
(n)annoyance, bother, botheration, pain, infliction, pain in the neck, pain in the ass, nuisancesomething or someone that causes trouble; a source of unhappiness“a bit of a bother”, “he's not a friend, he's an infliction”, “washing dishes was a pain in the neck before we got a dish washer”

Verbs

(v)trouble, ail, paincause bodily suffering to and make sick or indisposed
(v)pain, anguish, hurtcause emotional anguish or make miserable“It pains me to see my children not being taught well in school”