Nouns

(n)adversity, hardship, hard knocksa state of misfortune or affliction“debt-ridden farmers struggling with adversity”, “a life of hardship”
(n)asperity, grimness, hardship, rigor, rigour, severity, severeness, rigorousness, rigourousnesssomething hard to endure“the asperity of northern winters”
(n)hardshipsomething that causes or entails suffering“I cannot think it a hardship that more indulgence is allowed to men than to women” (James Boswell), “the many hardships of frontier life”