Adjectives

(s)annihilating, devastating, witheringmaking light of“afire with annihilating invective”, “a devastating portrait of human folly”, “to compliments inflated I've a withering reply” (W.S.Gilbert)
(s)annihilative, annihilating, devastating, witheringwreaking or capable of wreaking complete destruction“possessing annihilative power”, “a devastating hurricane”, “the guns opened a withering fire”
(s)crushing, devastatingphysically or spiritually devastating; often used in combination“a crushing blow”, “a crushing rejection”, “bone-crushing”