ˌpaɪəˈnɪəɹ ˌpaɪəˈnɪəɹ open up and explore a new area pioneer space take the lead or initiative in; participate in the development of This South African surgeon pioneered heart transplants open up an area or prepare a way She pioneered a graduate program for women students one of the first colonists or settlers in a new territory they went west as pioneers with only the possessions they could carry with them someone who helps to open up a new line of research or technology or art