ˈʃæɡ.ɹɪn ʃəˈɡɹɪn ˈɡaŋˌɡɹiːn ˈɡæŋˌɡɹin hjuːˌmɪliˈeɪʃən (Christianity) the act of mortifying the lusts of the flesh by self-denial and privation (especially by bodily pain or discomfort inflicted on yourself) an instance in which you are caused to lose your prestige or self-respect he had to undergo one humiliation after another strong feelings of embarrassment the localized death of living cells (as from infection or the interruption of blood supply)