kɹɒs kɹɔs ˈkɹɑːsˌbɹiːd ˈhaɪ.bɹɪd ˈhaɪ.bɹɪd ˈhaibɹidkɑː (genetics) an organism that is the offspring of genetically dissimilar parents or stock; especially offspring produced by breeding plants or animals of different varieties or breeds or species a mule is a cross between a horse and a donkey produced by crossbreeding a composite of mixed origin the vice-presidency is a hybrid of administrative and legislative offices a word that is composed of parts from different languages (e.g., ‘monolingual’ has a Greek prefix and a Latin root) a car which runs on two power sources, usually an internal combustion engine and an electronic motor