ɹæmɪfɪˈkeɪʃən ˌɹæməfəˈkeɪʃən the act or process of complicating puzzling complexity a development that complicates a situation the court's decision had many unforeseen ramifications a situation or condition that is complex or confused her coming was a serious complication any disease or disorder that occurs during the course of (or because of) another disease bed sores are a common complication in cases of paralysis