æn.tæ.ɡə.ˈnɪs.tɪk ˌɪŋkəmˈpætɪbəl incapable of harmonious association used especially of drugs or muscles that counteract or neutralize each other's effect arousing animosity or hostility his antagonistic brusqueness Europe was antagonistic to the United States characterized by antagonism or antipathy slaves antagonistic to their masters antipathetic factions within the party indicating opposition or resistance